|Location||University of Wollongong, Faculty of Science, Medicine and Health|
|Eligibility||Open to international applicants|
Electrical Stimulation for Directed Differentiation of Stem Cells
Based at St Vincent’s Hospital in Melbourne, this PhD project (administered by University of Wollongong will be undertaken to develop an electrically stimulated culture system and protocols for its application to the expansion of undifferentiated induced pluripotent stem cells (iPSCs) and/or specifically sub-differentiated iPSC-derived precursors for modelling and engineering neurological (CNS/neural), neuromuscular (PNS/muscle) and musculo-skeletal (myotendinous) structures. Specifically, the system to be developed will involve application of ultra-low fouling electrodes in various configurations to develop a comprehensive conducting technology for expansion of specific phenotypic sub-sets of stem cell populations.
Specifically this PhD will involve:
- Primary stem cell-biology to generate iPSC and specific (muscle/nerve) precursor cell types for engineering of neuromuscular, muscle and neural structures.
- Molecular biology required to characterise cells subjected to expansion/differentiation paradigms.
- liaise with materials/fabrication scientists from Swinburne and Deakin Universities to apply ultra-low fouling electrode configurations to develop efficient protocols for expansion of defined-phenotype stem cells.
The appointee will be a member of the Bionics Laboratory located within the Translational Bionics Fabrication node of the Intelligent Polymer Research Institute (IPRI) at St Vincent’s Hospital in Melbourne (SVHM) under supervision from Pr Robert Kapsa and Dr Anita Quigley. The activity will also involve significant utilisation of the BioFab3D@ACMD 3D biofabrication facility, of which Drs Quigley and Kapsa are members.
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