|Location||Garvan Institute of Medical Research, Garvan Institute of Medical Research|
|App. deadline||Applications accepted year round/until filled|
|Eligibility||Australian and New Zealand residents|
The pharmacogenomics of ion channels
Natural genetic variation in the human genome can result in alterations to the gene expression, post-transcriptional-processing and/or a protein’s amino acid composition. These individual genomic differences may cause different responses to medications and result in an underappreciated burden on public health. Although ion channels are ubiquitously expressed, contribute to all CNS functions and are targeted by almost a sixth of prescribed medicinal drugs, the prevalence and impact of genetic variation on this key gene family are unknown. In this project, we will analyse, collate and evaluate genomic, transcriptomic and structural data relevant to ion channel function with the aim of increasing prescription precision, improving patients’ quality of life, and relieving the economic and societal burden due to variable drug responsiveness.
This EMBL Australia affiliated project offers the opportunity to do great science in one of the best genomics and transcriptomics biomedical centres in the world, and to combine that with a great lifestyle in one of the best cities in the world.
All PhD students at the Garvan Institute must have a scholarship from The University of New South Wales or through another government, trust or philanthropic organisation. Before applying for a scholarship, you must have agreed on a project with an institute supervisor.
See our full disclaimer