|Location||Monash University, Australian Regenerative Medicine Institute|
|Eligibility||Australian residents only|
Effect of age-related epigenetic changes in neural stem/progenitor cells upon remyelination of the brain
Myelin regeneration is critical for preventing axonal loss in patients with multiple sclerosis and in animal models of demyelination. Dr. Merson’s group has demonstrated that both oligodendrocyte progenitor cells (OPCs) and neural stem/progenitor cells (NSPCs) can regenerate myelin in young mice and that the myelin regenerated by NSPCs is superior to that produced by OPCs. Ageing reduces the regenerative capacity of both OPCs and NSPCs. Whilst age-related epigenetic modifications in OPCs have been shown to reduce their regenerative capacity, this has not been explored for NSPCs. This project will compare the epigenetic changes in NSPCs and OPCs during ageing and develop approaches to restore youthful chromatin structures in these populations to enhance remyelination in aged mice.
Research Website: https://www.mersonlab.org/
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