|Location||Monash University, Australian Regenerative Medicine Institute|
|Eligibility||Australian residents only|
Mechanisms regulating germline progenitor cell identity and fate
Maintenance of male fertility is dependent on a population of germline stem cells within the testis (known as spermatogonial stem cells or SSCs). Transition of SSCs to a committed progenitor fate is essential for generating cohorts of differentiating germ cells and spermatozoa. While molecular mechanisms responsible for SSC-to-progenitor transition are poorly appreciated, our data indicates that the transcription factor SOX3 is essential for stable adoption of a committed progenitor state. Using novel reporter models, Sox3 deficient mice and genome-wide analysis approaches, this project will define molecular features of SSC and progenitor populations and the role of SOX3 plus cooperating factors in defining progenitor cell identity and function.
This project will be performed in partnership with researchers at the Chinese University of Hong Kong (CUHK) and will involve travel to the partner institute. Scholarship funding for this project is already available.
Research webpage http://www.armi.org.au/about/our-people/robin-hobbs
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