|Location||University of Newcastle, Immunology and Microbiology|
|App. deadline||Applications accepted year round/until filled|
|Eligibility||Australian residents only|
Elucidating the roles and therapeutic targeting of oxidative stress and immunometablism in chronic obstructive pulmonary disease (COPD)/emphysema
COPD is currently the third commonest cause of illness and death in the world and there are essentially no effective treatments. The pathogenesis of COPD is driven by oxidative stress in mitochondria and inflammation. Epithelial cells and macrophages are prominent sources of oxidative stress and inducers of inflammation. Macrophages occur in different phenotypes with different functions and properties that can be modified by treatment. We have developed novel inhibitors of mitochondrial oxidative stress and modulators of cellular metabolism and have evidence that they suppress oxidative stress and inflammation. In this project we will 1. Test the efficacy of anti-oxidants and 2. Metabolic modulators as potential treatments in mouse models of experimental COPD that we have developed, and 3. In human broncho-epithelial cells and macrophages. This project has the potential to develop new preventions and treatments for COPD. There is the potential to undertake some of this work in Dublin, Ireland.
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