Location University of Technology Sydney, ithree Institute

Cytoskeletal protein function in the control of archaeal cell shape and division

Our team seeks to gain a molecular understanding of microbial cell shape and structural responses to change and stress. We are leading the development of Haloferax volcanii as a powerful model microorganism for molecular cell biology, and for understanding cytoskeletal protein function and evolution. With this model, we have discovered the roles of two new families of cytoskeletal proteins from the tubulin-FtsZ superfamily in archaea (Duggin et al. 2015 Nature 519:362).

These PhD projects aim to understand how these proteins function to control cell shape and division, by (1) building a “ground-up” understanding of their ability to remodel the cell envelope, and (2) discovering the function of novel proteins linked to the cytoskeleton. The projects will involve methodological innovation and development, and the utilization of cutting-edge technology, including recombinant DNA and molecular genetics, high-resolution fluorescence or electron microscopy, and protein structure and function studies.

Scholarships and application details: https://www.uts.edu.au/future-students/science/science-courses/research-courses/phd-scholarships/microbial-structural-dynamics

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Further Information / Application Enquiries

A/Prof Iain Duggin