Applications for this PhD have now closed.
Location Monash University, Australian Regenerative Medicine Institute
Discipline
App. deadline 12/12/2017
Funding
  • Scholarship available
Eligibility Australian residents only

Strategies to enhance the immunomodulatory capacity of mesenchymal stem cells

Industry-based PhD programs

Strategies to enhance the immunomodulatory capacity of mesenchymal stem cells 

Company: Regeneus Ltd

Supervisors: Dr Tracy Heng (Monash University), Professor Laurence Meagher (Monash University), Dr Graham Vesey (Regeneus Ltd).

Background: Mesenchymal stem cells (MSCs) have shown great therapeutic potential as a versatile cell therapy product and are being used to treat a broad range of inflammatory disease conditions. Although predominantly known for their anti-inflammatory and immunosuppressive properties, MSCs can also promote immune responses under certain conditions. Understanding how to manipulate this unique dual function of MSCs is key to broadening their clinical use to boost immune responses, e.g. in vaccines.

Project aims: To develop strategies to manipulate the immune-modifying properties of MSCs and investigate their capacity to enhance vaccine-specific responses.

Techniques: This Project will utilise techniques applicable to both stem cell research and immunology, including stem cell isolation, cell/tissue culture, multi-lineage differentiation assays, flow cytometry, in vivo T cell assays, cytokine ELISPOT and multiplex assays, serum antibody ELISA, disease models etc.

Ideal candidate: This is an exceptional opportunity to work in close partnership with an Australian regenerative medicine company. The Project will suit a highly motivated candidate with an immunology background, who is interested in translational research in a cross-disciplinary academic setting with strong industry links. The PhD candidate will conduct some parts of the research program interstate at the laboratory of our industry partner.

For all questions, and information on how to apply, contact Dr Tracy Heng via tracy.heng@monash.edu

Applications close November 30th 5 pm AEDT. 

Exceptional PhD candidates will be granted the equivalent to a RTP Stipend (formerly Australian Postgraduate Award), 2017 rate A$26,682 p.a. for three years.



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