|Location||Queensland University of Technology, Science and Engineering Faculty|
|Eligibility||Open to international applicants|
Industrial biotechnology for improved manufacture of medicinal alkaloids
This PhD project will specifically involve research to discover, characterise, optimise and express a key enzyme in the production pathway. The project will investigate fundamental scientific questions while maintaining a strong industry focus. The overall project aims to develop a new semi‐synthetic route for the manufacture of codeine.
Codeine is manufactured by the chemical conversion of poppy‐derived morphine, which is low-yielding and environmentally unfriendly. Two enzymes will be investigated and optimised, and an innovative bioreactor to achieve high yield will be developed.
The resulting industrial biotransformation will provide a greener and cheaper process for increased global access to codeine. Australian opiate manufacturing is expected to benefit from value-adding and increased flexibility introduced by a biotechnology approach.
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