|Location||University of Tasmania, School of Medicine|
|Eligibility||Open to international applicants|
Pericyte regulation of blood flow in the brain and its dysfunction following stroke
A PhD scholarship is available within the School of Medicine at the
University of Tasmania to investigate the role of pericytes in the brain
during health and following stroke. Pericytes are contractile cells located
exclusively on capillaries. They have key roles in maintaining the
blood-brain barrier, vascular development, angiogenesis and regulating the
passage of inflammatory cells into the brain. In addition, they can
regulate capillary diameter and therefore control the delivery of blood
flow to the brain. Following stroke, pericytes contract and die in rigor,
leaving the capillaries shut meaning restoration of blood flow is limited.
This project will use in vitro cell culture techniques to investigate human
pericytes in isolation and determining mechanisms of pericyte contraction
and dilation which could influence blood flow in the brain. In vivo models
of stroke will also be used to assess how pericytes are clamping
capillaries shut and subsequently dying. The student will develop skills in
cell culture, qPCR, biochemical assays, in vivo models of stroke and
microscopy. They will use both pharmacological and genetic strategies to
determine pericyte-specific mechanisms and uncover novel pericyte-acting
compounds that may protect the brain after a stroke.
This is a living allowance scholarship funded by the University of Tasmania and will be funded at the 2017 RTP rate of AUD$26,682 per annum as a living allowance for 3 years, with a possible 6 month extension.
The scholarship is open to Australian (domestic) candidates and International candidates and applicants must already have been awarded a first class Honours degree or hold equivalent qualifications or relevant and substantial research experience in an appropriate sector. Applicants must be able to demonstrate strong research and analytical skills and meet English Language requirements. Basic expertise and experience is required in one or more of the following areas: neuroscience, vascular biology, animal models, molecular biology and histology techniques, and/or microscopy. Candidates from a variety of disciplinary backgrounds are encouraged to apply.
Applicants should email a CV including publication record, copies of their transcripts and contact details for at least 2 referees to Dr Brad Sutherland (firstname.lastname@example.org). Please contact Brad if you require any more information.
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